Unlocking the secrets of SARS-CoV-2

During the pandemic, we analysed all structures of nsp3. Non-structural protein 3 (nsp3) is the largest protein of the SARS-CoV-2 virus. It has over a dozen parts ("domains") with different jobs The virus needs nsp3 to multiply and therefore, it is a major target for drugs against COVID.
However, while we know what some of the domains look like, for the whole nsp3, there is only a very low resolution "blobby" structure. With this paper we use our analysis, AI-based prediction and additional experiments to shed light on the overall structure, with implications how nsp3 works in the infected cell.

The article is Open Access and available here:
Unlocking the secrets of SARS-CoV-2 nsp3 by combining experiments with AlphaFold2 domain prediction